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本研究の一部は，公益財団法人天田財団の一般研究開発助成AF 2016225 によっておこなわれたものであり，ここに感謝の意を表します．本研究本研究の遂行にあたり，本実験を実際に遂行いただきました飯野敬矩博士，山川健氏，萩原宏規氏，荒木崇志氏，前田祐希氏，井上一輝氏，釣優香博士，および関係諸氏に感謝します． 1) Y. Hosokawa: Applications of the femtosecond laser-induced impulse to cell research, Jpn. J. Appl. Phys., 58, (2019), 110102. 2) T. Kaji, S. Ito, H. Miyasaka, Y. Hosokawa, H. Masuhara, C. Shukunami and Y. Hiraki: Nondestructive micropatterning of living animal cells using focused femtosecond laser-induced impulsive force, Appl. Phys. Lett., 91, (2007), 23904. 3) C. Hosokawa, M. Suzuki, T. Taguchi, A. Kiyohara, S. N. Kudoh, Y. Hosokawa, K. Okano, and H. Masuhara: Micro-channel fabrication by femtosecond laser to arrange neuronal cells on multi-electrode arrays, Appl. Phys. A, 101, (2010), 423–428. 4) Y. Maezawa, K. Okano, M. Matsubara, H. Masuhara, and Y. Hosokawa: Morphological evaluation of cell differentiation after the isolation of single cells by a femtosecond laser-induced impulsive force, Biomed. Microdevices, 13, (2011), 17–122. 5) A. Yamaguchi, Y. Hosokawa, G. Louit, T. Asahi, C. Shukunami, Y. Hiraki, and H. Masuhara: Nanoparticle injection to single animal cells using femtosecond laser-induced impulsive force, Appl. Phys. A, 93, (2008), 39–43. 6) Y. Hosokawa, S. Iguchi, R. Yasukuni, Y. Hiraki, C. Shukunami, and H. Masuhara: Gene delivery process in a single animal cell after femtosecond laser microinjection, Appl. Surf. Sci., 255, (2009), 9880–9884. 7) Y. Hosokawa, H. Ochi, T. Iino, A. Hiraoka, and M. Tanaka: Photoporation of Biomolecules into Single Cells in Living Vertebrate Embryos Induced by a Femtosecond Laser Amplifier, PloS One, 6, (2011), e27677. 8) T. Maeno et al.: Targeted delivery of fluorogenic peptide aptamers laser photoporation at single-cell resolution, Sci. Rep., 8, (2018), 8271. live microalgae by femtosecond into 9) Z. Y. Hong, K. Okano, D. Di Carlo, K. Tanaka, Y. Yalikun, and Y. Hosokawa: High-speed micro-particle manipulation 謝 辞 参考文献 in a microfluidic chip by directional femtosecond laser impulse, Sens. Actuators A, 297, (2019), 111566. 10) T. Iino et al.: High-speed microparticle isolation unlimited by Poisson statistics, Lab on a Chip, 19, (2019), 2669–2677. 11) Y. Hosokawa, J. Takabayashi, T. Omoto, T. Adachi, K. Fujiyama, T. Seki, and H. Masuhara: Nondestructive Manipulation of Single Live Plant Cell by Laser Induced Micro Shockwave, Proc. Int’l Colloq. on Plant Biotech., (2013), 53–57. 12) A. Vogel and V. Venugopalan: Mechanisms of Pulsed Laser Ablation of Biological Tissues, Chem. Rev., 103, (2003), 577–644. 13) T. Ando, S. Sato, S. Takano, H. Ashida, and M. Obara: Propagation characteristics of laser-induced stress wave in deep tissue for gene transfer, Appl. Surf. Sci., 255, (2009), 9898–9901. 14) A. Vogel et al.: Energy balance of optical breakdown in water at nanosecond to femtosecond time scales, Appl. Phys. B, 68, (1999), 271–280. 15) T. Iino and Y. Hosokawa: Direct Measurement of Femtosecond Laser Impulse in Water by Atomic Force Microscopy, Appl. Phys. Express, 3, (2010), 107002. 16) Y. Hosokawa, M. Hagiyama, T. Iino, Y. Murakami, and A. Ito: Noncontact estimation of intercellular breaking force using a femtosecond laser impulse quantified by atomic force microscopy, Proc. Natl Acad. Sci. USA, 108, (2011), 1777–1782. 17) T. Iino and Y. Hosokawa: Controllability of femtosecond laser-induced impulse in water evaluated by local force measurement system using atomic force microscopy, J. Appl. Phys., 112, (2012), 66106. 18) T. Iino, P. L. Lin, W. Z. Wang, J. H. Deng, Y. C. Lu, F. J. Kao, and Y. Hosokawa: Contribution of stress wave and cavitation bubble in evaluation of cell–cell adhesion by femtosecond laser-induced impulse, Appl. Phys. A, 117, (2014), 389–393. 19) R. Yasukuni, R. Fukushima, T. Iino, and Y. Hosokawa: Pulsed-laser-activated impulse response encoder: Sensitive detection of surface elastic waves on biomimetic microsized gel spheres, Appl. Phys. Express 10, (2017), 117007 20) R. Yasukuni, D. Minamino, T. Watanabe, S. Yamada, T. Iino, Y. Bessho, T. Matsui, Y. Hosokawa: Pulsed-laser-activated impulse response encoder (PLAIRE): Detection of core–shell structure of biomimetic micro gel-sphere, Appl. Phys. A 124, (2018), 594. - 72 -